In the summer of 2021, Christina Applegate bravely shared her multiple sclerosis diagnosis, sparking conversations about the autoimmune disease. Recently, the actress expressed her aspirations, revealing her desire to work with Shirley MacLaine and enjoy shots with Cher. Applegate's admiration for MacLaine is evident, as she tearfully expressed her lifelong dream of collaborating with the iconic actress. Despite her health challenges, Applegate continues to shine in the entertainment industry, receiving a standing ovation at the Emmy Awards and launching the podcast, MeSsy, to raise awareness about MS. Through her candidness and humor, Applegate is not only navigating life with MS but also inspiring others with her resilience and determination. Her openness about her journey with MS serves as a reminder of the importance of staying positive and pursuing dreams no matter the obstacles.