Christina Applegate opens up about her battle with multiple sclerosis, expressing her desires for her final days. Despite facing a tough road since her 2021 diagnosis, Applegate remains resilient. After wrapping up her Netflix hit Dead to Me in 2022, she is unlikely to return to on-camera work. Instead, she has ventured into podcasting, cohosting the show MeSsy with fellow actress Jamie Lynn Sigler, who also has MS. In a recent episode, Applegate's daughter revealed her own health challenges. Applegate's candidness has garnered an outpouring of support from fans. She shares her aspirations to work with Shirley MacLaine and share shots with Cher in her remaining days. As she navigates her health journey, Applegate continues to inspire with her strength and determination.