The highly-anticipated standalone sequel to the 1996 disaster epic "Twister," aptly titled "Twisters," is set to make a stormy entrance at the North American box office this weekend, with an expected $50-55 million opening in 4,000 theaters. Directed by acclaimed filmmaker Lee Isaac Chung and starring Daisy Edgar-Jones, Glen Powell, and Anthony Ramos, the film follows a group of storm chasers battling multiple tornadoes in central Oklahoma. With a hefty $155 million production budget, Universal is banking on "Twisters" to make a global impact and justify its costs. While the original "Twister" was a massive success, the sequel has received mixed reviews, with critics praising the spectacle but noting it falls short of its predecessor's charm. As the summer box office heats up, "Twisters" faces tough competition from recent hits like "Inside Out 2" and "Despicable Me 4," but the Hollywood buzz is building for upcoming releases like "Deadpool & Wolverine" in the coming weeks.